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특허상세정보
Title  NSUBSTITUTED 2CYANOPYRROLIDINES
PCT Pub. No.  WO2000-034241
PCT Appl. No.  PCT-EP1999-009708
PCT Appl. Date  1999-12-09
Applicant  NOVARTIS AG
Inventors  VILLHAUER, Edwin, Bernard(US) NOVARTISERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH(AT)
(1st) Priority  US 09/209068
Priority Date  1998-12-10
Appl. No.  1-2001-00630
Appl. Date  1999-12-09
Patent No.  1-0005529-000
Issued Date  2006-03-15
Status  In Force
Expiration Date  2019-12-09
Attached File -
Abstract  The present invention relates to a compound of formula (I), wherein R is substituted adamantyl; and n is 0 to 3; in free form or in acid addition salt form. Compounds of formula (I) inhibit DPPIV (dipeptidylpeptidaseIV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPPIV and in the treatment of conditions mediated by DPPIV, such as noninsulindependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
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